It is primarily used to treat bipolar disorder and treat major depressive disorder that does not improve following the use of antidepressants. A two years study", "Lithium orotate, carbonate, and chloride: pharmacokinetics, polydipsia and polyuria in rats", "Lithium toxicity from an Internet dietary supplement", "Vitamin B13 cannot be proven safe, says EFSA", https://en.wikipedia.org/w/index.php?title=Lithium_orotate&oldid=963440355, Articles with changed ChemSpider identifier, Chemical pages without DrugBank identifier, Drugboxes which contain changes to verified fields, Drugboxes which contain changes to watched fields, Creative Commons Attribution-ShareAlike License, This page was last edited on 19 June 2020, at 20:28. Lithium alternatives may offer a better option for addressing mood swings than you may have been presented before. 18. J Pharm Pharmacol 1979;31:161-3.. View abstract. I don't think it had any beneficial effect. 0 m equiv kg−1 lithium carbonate, two‐thirds of the 2 h serum lithium concentration was present 24 h after lithium orotate. Concerns have been raised in medical literature after a case report of a patient who required medical attention after taking an overdose of lithium orotate supplement. You often see it suggested online that lithium-orotate is better absorbed from the intestines than lithium-carbonate but in fact there appears to be little difference in this regard. Only thing I have issues with are hand shakes and slight tremors in the morning. In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion, and like other salts, dissociates in solution to produce free lithium ions. Lithium orotate dosage depends on the condition that is being treated. What have you got to lose? It is helpful in making the highs and lows less as research suggests lithium works to reduce mood swings and enhance feelings of well-being, when taken regularly. Smith DF, Schou M. Kidney function and lithium concentrations of rats given an injection of lithium orotate or lithium carbonate. It’s a member of the alkali earth metals family of elements which puts it in the same class as such minerals as sodium and potassium. Please re-enable javascript to access full functionality. The Benefits of Lithium Orotate. I started lithium a few weeks ago I think. Lithium orotate has the ability to potentially improve cognitive function, enhance mood, and increase bone strength. [14], InChI=1S/C5H4N2O4.Li/c8-3-1-2(4(9)10)6-5(11)7-3;/h1H,(H,9,10)(H2,6,7,8,11);/q;+1/p-1, "The clinical applications of lithium orotate. It did give me diarrhea. Some of the reviews on Amazon mentioned it helping Bipolar Disorder and other mental illnesses (though I'm always suspicious of Amazon reviews). Lithium orotate stabilizes the lysosomal membranes and prevents the enzyme reactions that are responsible for the sodium depletion and dehydration effects of other lithium salts. It supposedly controls mood swings. A friend of mine mentioned her anxiety has vanished since she began taking it daily, and recommended it to me. I read on another forum someone taking lithtium orotate and claims it helped reduce their DP with 60% so I'm going to try it. Whatever version that requires a prescription. Lithium Orotate at low doses is non-toxic and lab tests are not required to monitor your lithium levels because it does not show up in blood samples. This, along with L-theanine, has greatly reduced my anxiety, depression, agitation, repetitive thoughts and helps me sleep. Lithium calms mania and mood swings by decreasing the sensitivity of norepinephrine receptors. Lithium salts are chemical salts of lithium used mainly in the treatment of bipolar disorder as mood stabilizers. Lithium (especially Lithium Orotate) really is the misunderstood mineral! Suggested Use: Not to be taken by pregnant and lactating women. Furthermore, the 24 h brain concentration of lithium after lithium orotate was approximately three times greater than that after lithium carbonate. Books Advanced Search Amazon Charts Best Sellers & more Top New Releases Deals in Books School Books Textbooks Books Outlet Children's Books Calendars & Diaries Advanced A healthy individual can benefit from taking as little as one milligram, while a depressed patient needs 20 to 30 milligrams a day, split into several doses. [7][8][9], Lithium orotate's safety remains in question. I think they are one in the same though, somehow. There are two forms of lithium available to consumers: there is a natural form of the metal/mineral (lithium orotate), considered to have neuroprotective characteristics. I don't find myself as thirsty as I was in the beginning and yeah decreased appetite but its slowly coming back. A friend of mine mentioned her anxiety has vanished since she began taking it daily, and recommended it to me. Noncontrolled studies have examined the use of low-dose lithium orotate in the treatment of alcoholism, migraines, and depression associated with bipolar disorder. Wondering if it will have any affect on DP. Lithium compounds, also known as lithium salts, are primarily used as a psychiatric medication. Because of the superior bioavailability of lithium orotate, the therapeutic dosage is much less than prescription forms of lithium. Sartori HE, Lithium orotate in the treatment of alcoholism and related conditions, Alcohol 1986 Mar; 3 (2): 97-100. Relentless Improvement Lithium Orotate is well priced and it works. Lithium is classified as an essential nutrient, and some of its salts are naturally found in food and drinking water. In addition, lithium orotate is available without a prescription, unlike lithium carbonate, which is considered a prescription drug by the Food and Drug Administration (FDA). Lithium is taken by mouth. [6] The proponents of lithium orotate have since criticized the results by citing the fact that the dose of lithium orotate used in the study was in the toxic range. edit: I got some, going to try 5mg daily for month or two and I guess I'll report … Mechanism unknown according to google. [10][11][12], Orotic acid can be mutagenic in very high doses of 50 mg/kg in mammalian somatic cells. Lithium Orotate Benefits. Lithium orotate (lithium bound with a natural chemical called orotic acid, found in breast milk 7 and certain root vegetables, available as a supplement without a prescription) There have been many other compounds/mixtures produced over the last century and a half. The orotate form of lithium is used by doctors to help stabilize and equilibrate mood. They are also sometimes used to treat depression and mania. The pharmacokinetics of lithium orotate in human brains is poorly documented, and there is no known mechanism by which orotate ions could alter the pharmacokinetics of dissociated lithium ions. Wondering if anybody out there has experience with this supplement. When taken in low doses and in the right form, it's an amazing supplement that can help us all feel a whole lot better!! Lithium orotate — known by the names lithium carbonate, lithium citrate and simply lithium — is a compound used to treat a number of neurological conditions 1. Major medical research has not been conducted on lithium orotate since the 1980s due to its patent status and the abundant availability of lithium carbonate. Disclaimer: I am in no way, shape or form associated with Lithium Orotate or any company that deals with it in any way. Available in dietary supplement form, lithium orotate is touted as a natural treatment for a wide range of mental health problems. FREE Shipping on orders over $25 shipped by Amazon. Not to be taken in conjunction with SSRIs or MAOIs unless advised by a health professional. And there is its synthesized counterpart (lithium carbonate). It has also been known to be used to manage depression, mental health issues, and alcoholism.Let us look at the benefits in detail. Give it a shot. Lithium is an element. Lithium-orotate is the alternative non-prescription form of lithium I use both personally and prescribe in my practice. Lithium orotate is an elemental substance that is also an essential micronutrient. Clinical trials involving 150 mg daily doses of lithium orotate administered 4 to 5 times a week, showed a reduction of manic and depressive symptoms in bipolar patients [50]. As previously stated, lithium intake appears to be effective even at low doses, and this may account for lithium orotates claimed effectiveness. Nieper HA The curative effect of a combination of Calcium-orotate and Lithium orotate on primary and secondary chronic hepatitis and primary and secondary liver cirrhosis. There was a woman on 120mg of lithium orotate who went toxic after 22 days (just read the article earlier today, sorry lost the link, I was doing personal research, as I am asking myself the same question about orotate, and having difficulties finding the answers I need). We use cookies to improve your experience on this website and so that ads you see online can be tailored to your online browsing interests. By continuing to browse our site you agree to our use of data and cookies. Lithium (orotate) - Pure Prescriptions. Some of the reviews on Amazon mentioned it helping Bipolar Disorder and other mental illnesses (though Im always suspicious of Amazon reviews). It is possible that certain formats are more effective and/or safer than others in the specific domain of anxiety disorders. [5] This study was refuted a year later by another study that repeated the experiment and found that the higher concentrations in the brain could be possibly accounted for by decreased renal function in rats treated with lithium orotate. I can make better long-term decisions and I'm more optimistic about the future. Over-the-counter lithium orotate is promoted as a health supplement for use as a low-dose source of lithium; however, very limited clinical evidence exists to support use. [13] It is also mutagenic for bacteria and yeast. What Does Lithium Orotate Do to the Brain? There are a lot of brands on Amazon, ranging from 5mg to 120mg, so it's really confusing which one to buy, and I can't find much research on the internet about it. 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